Shuffle

When affected by a Shuffle, your character's stats (strength, dexterity, and intelligence) will be permanently and irreversibly rearranged. When carefully and intentionally performed, this can allow for dramatic changes in your playstyle; when done accidentally, this can ruin your character. As such, they are extremely rare and easy to avoid if you don't want to take the chance:

• You can find Shuffle cards in ornate or legendary decks of wonders and decks of changes. Drawing one immediately rearranges your stats to a random new configuration. This is a very good reason to avoid haphazardly drawing random cards from unidentified decks.
• Jiyva will occasionally hit you with Shuffles, but these will be weighted to benefit you based on your current skills, inventory weight, and the evasion penalty of your worn armour.