Deterioration

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Rank Effect Flavor
1 Periodic temporary stat loss. Your body is slowly deteriorating.
2 More frequent temporary stat loss. Your body is deteriorating.
3 Most frequent temporary stat loss. Your body is rapidly deteriorating.

A ring of sustain abilities will negate this. Natural recovery from stat loss tends to keep rank 1 in check, though not always. Left unchecked, ranks 2 and 3 will leave you extremely handicapped, and will eventually result in stat zero.

Bad mutation