Potion of mutation

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Version 0.28: This article may not be up to date for the latest stable release of Crawl.
A potion which mutates the drinker, removing several mutations then granting a few random mutations, which are likely (but not guaranteed) to be beneficial.
Type Potion
Name Potion of Mutation
Icon Potion of mutation.png

A surprise in every bottle! When drunk, potions of mutation first remove 2-3 mutations, then add 1-3 random mutations (each with a 60% chance of being good), then have a 50% chance to add one good mutation.

Mutations added by this potion are affected by mutation resistance. Characters that have either the mutation resistance intrinsic or are using the hat of the Alchemist or lajatang of Order will mostly lose mutations when drinking this potion; characters that are already heavily mutated are also less likely to gain further mutations.

Followers of Zin incur penance if they knowingly drink this potion at less than ****** (160) piety. Once that piety threshold has been reached, however, Zin suppresses the mutation-adding effects of the potion, so followers can drink it to only remove mutations.

Note that Ghouls cannot use this potion, but drinking an unidentified potion of mutation will cause them to suffer stat drain.


  • Prior to 0.27, potions of mutation removed 2-4 mutations and provided a guaranteed good mutation.
  • Prior to 0.21, potions of mutation removed 2-6 random mutations instead of 2-4.
  • Prior to 0.20, potions of mutation just attempted to give 1-3 random mutations, with separate potions of beneficial mutation and potions of cure mutation.
AmbrosiaAttractionBerserk rageBrillianceCancellationCuringDegenerationEnlightenmentExperienceHasteHeal woundsInvisibilityLignificationMagicMightMutationResistance