Creatures with the cold blooded blood temperature are unique only in that they are particularly vulnerable to certain cold-based attacks. They have a 50% chance of being slowed when they are damaged by any of the following cold sources:
- Freezing-branded melee attacks
- standing next to walls that have been affected by Frozen Ramparts
- Ozocubu's Refrigeration
- Freezing Cloud
They are also more strongly affected by Metabolic Englaciation, remaining slowed for twice as long.
Notably, Hydras are cold-blooded monsters. As a melee character, if you don't have a slicing flaming weapon to deal with them, another good strategy is using a non-slicing cold weapon to slow them. Other early game examples include the various snakes, lizards, and frogs.
The draconians that populate the Realm of Zot are also cold-blooded. This can mean that the freezing brand is sometimes preferable to the flaming brand in the late game. This also includes player draconians -- until you find a source of cold resistance (or develop white scales), you will be equally susceptible to cold.
For a full list of cold-blooded monsters, see Category:Cold-blooded.